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Merck
CN

774766

Lithium diisopropylamide solution

1.0 M in THF/hexanes

Synonym(s):

LDA

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About This Item

Linear Formula:
[(CH3)2CH]2NLi
CAS Number:
4111-54-0
Molecular Weight:
107.12
UNSPSC Code:
12352001
NACRES:
NA.22
PubChem Substance ID:
329767712
MDL number:
MFCD00064449
Beilstein/REAXYS Number:
3655042

Key Documents

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Product Name

Lithium diisopropylamide solution, 1.0 M in THF/hexanes

InChI

1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1

SMILES string

[Li]N(C(C)C)C(C)C

InChI key

ZCSHNCUQKCANBX-UHFFFAOYSA-N

form

liquid

concentration

1.0 M in THF/hexanes

density

0.719 g/mL at 25 °C

functional group

amine

storage temp.

2-8°C

Quality Level

200

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Application

Titanium-ate enolates prepared from ketones by Ti(OiPr)4 and LDA underwent efficient radical trifluoromethylation providing trifluoromethyl ketones in good yield. Used in directed ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.

General description

This material is in a solution of THF/Hexanes (ca. 1:7 ratio, respectively)

Packaging

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Pyr. Liq. 1 - Repr. 2 - Skin Corr. 1B - STOT RE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system, Respiratory system

supp_hazards

EUH014,EUH019

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

wgk

WGK 3

flash_point_f

-7.6 °F - closed cup

flash_point_c

-22 °C - closed cup

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SHBS8893
SHBS2486
SHBR7019
SHBR2555
SHBP9072

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Tetrahedron Letters, 47, 6405-6405 (2006)
Journal of Fluorine Chemistry, 127, 539-539 (2006)
Martin E Gosnell et al.
Biochimica et biophysica acta, 1863(1), 56-63 (2015-10-04)
Hyperspectral imaging uses spectral and spatial image information for target detection and classification. In this work hyperspectral autofluorescence imaging was applied to patient olfactory neurosphere-derived cells, a cell model of a human metabolic disease MELAS (mitochondrial myopathy, encephalomyopathy, lactic acidosis
Joshua D Schaefferkoetter et al.
Physics in medicine and biology, 60(14), 5543-5556 (2015-07-03)
In the context of investigating the potential of low-dose PET imaging for screening applications, we developed methods to assess small lesion detectability as a function of the number of counts in the scan. We present here our methods and preliminary
Juan Eugenio Iglesias et al.
NeuroImage, 115, 117-137 (2015-05-06)
Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. Here we describe the construction of a statistical atlas of the
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