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779776

Methyl-β-cyclodextrin

Name: Methyl-β-cyclodextrin
Brand: ALDRICH

Wacker Chemie AG, ≥95.0% cyclodextrin basis (calculated)

Synonym(s):

Cavasol^® W7 M, Methyl-beta-cyclodextrin

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About This Item

CAS Number:

128446-36-6

MDL number:

MFCD00066764

UNSPSC Code:

12352201

NACRES:

NA.22

Assay:

≥95.0% cyclodextrin basis (calculated)

Form:

powder

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Properties

Quality Level

100

assay

≥95.0% cyclodextrin basis (calculated)

form

powder

manufacturer/tradename

Wacker Chemie AG

extent of labeling

1.6-1.9 molar substitution

impurities

≤0.2% unsubstituted cyclodextrin, ≤0.2% volatile organics, ≤2% chloride

loss

≤7.0% loss on drying

mp

180-182 °C (lit.)

SMILES string

O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI key

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

Description

Application

Methyl-β-cyclodextrin (M-β-CD) can be used as a reactant to prepare ternary inclusion complex of diclofenac (DCF) in the presence of monoethanolamine (MEA). This complex improves the percutaneous absorption of DCF in human skin. It can also be used to form an inclusion complex with olanzapine (OLP) to increase its solubility for efficient drug delivery.

Other Notes

For R&D Use

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

368.6 °F

flash_point_c

187 °C

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Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-beta-CD and monoethanolamine and in vitro transdermal evaluation.

María Julia Mora et al.

European journal of medicinal chemistry, 45(9), 4079-4088 (2010-06-23)

Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state.

Inclusion complex of methyl-β -cyclodextrin and olanzapine as potential drug delivery system for schizophrenia

de Freitas MR, et al.

Carbohydrate Polymers, 89(4), 1095-1100 (2012)

Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.

Maoyong Fu et al.

PloS one, 6(5), e19945-e19945 (2011-06-04)

Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival is epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate with and modify surface expression

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Global Trade Item Number

SKU	GTIN
779776-500G	04061833552377
779776-10KG	04061833381380
779776-100G	04061832941127