Merck
CN
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文件

779776

Sigma-Aldrich

甲基-β-环糊精

produced by Wacker Chemie AG, Burghausen, Germany, ≥95.0% cyclodextrin basis (calculated)

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别名:
Cavasol® W7 M
CAS号:
128446-36-6
NACRES:
NA.22

等级

produced by Wacker Chemie AG, Burghausen, Germany

质量水平

100

检测方案

≥95.0% cyclodextrin basis (calculated)

形式

powder

标记范围

1.6-1.9 molar substitution

杂质

≤0.2% unsubstituted cyclodextrin
≤0.2% volatile organics
≤2% chloride

缺失

≤7.0% loss on drying

mp

180-182 °C (lit.)

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI key

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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应用

在单乙醇胺(MEA)存在下，甲基-β-环糊精（M-β-CD）可作为反应物制备双氯芬酸(DCF)三元包合物。该复合物改善了DCF在人体皮肤中的经皮吸收。它也可用于与奥氮平(OLP)形成包合物，用于提高其溶解度，以实现有效的药物递送。

其他说明

仅供R&D使用

法律信息

Cavasol is a registered trademark of Wacker Chemie AG

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

368.6 °F

闪点(°C)

187 °C

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María Julia Mora et al.
European journal of medicinal chemistry, 45(9), 4079-4088 (2010-06-23)
Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state.
Inclusion complex of methyl-β -cyclodextrin and olanzapine as potential drug delivery system for schizophrenia
de Freitas MR, et al.
Carbohydrate Polymers, 89(4), 1095-1100 (2012)
Sara Rodríguez-Acebes et al.
The Biochemical journal, 420(2), 305-315 (2009-03-06)
Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol
Mario Menschikowski et al.
Cancer cell international, 11, 4-4 (2011-02-16)
Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out
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The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity
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