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790249

Poly(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(D,L-lactide-co-glycolide) based poly(ether ester urethane)

average Mn (6,000-15,000)

Synonym(s):

PEEU, PLGA-PEG-PLGA urethane, VISCOPRENE® 9, poly(ester ether urethane)

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About This Item

Linear Formula:
[C2H2N2O2R[(C3H4O2)x(C2H2O2)y]m[C2H4O]lO[(C3H4O2)x(C2H2O2)y]m]n
UNSPSC Code:
12352100
PubChem Substance ID:
329768204
NACRES:
NA.23
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form

amorphous solid

feed ratio

13:(70:17) (PEG:(D,L-lactide:glycolide)), lactide:glycolide 80:20

mol wt

PEG average Mn 400, average Mn (6,000-15,000)

degradation timeframe

<4 months

transition temp

Tg <0 °C

PDI

<2.0

storage temp.

2-8°C

SMILES string

CC(N[R]NC(OC(C)C(OCC(OCCOC(C(C)OC(COC)=O)=O)=O)=O)=O)=O.CC(N[R]NC(OCCCOC)=O)=O

Application

This poly(ether ester urethane) based on PLGA-PEG-PLGA triblock copolymers linked with a diisocyanate is a biodegradable, resorbable gel former for use in drug delivery systems. This polymer doesn′t rely on temperature or pH to induce gelation, and therefore forms more consistent and faster-setting drug delivery depots. Through combination of various gel formers and/or diluents, drug release profiles may be modulated to exhibit fast burst release through extended (up to 1 month) zero-order release profile. Mass loss of the resultant drug delivery depots is complete within 4 months.

Legal Information

Product of Poly-Med, Inc. VISCOPRENE® is a registered trademark of Poly-Med, Inc.
Viscoprene is a registered trademark of Poly-Med, Inc.

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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