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792373

2-Chloro-2,2-difluoroacetophenone

Name: 2-Chloro-2,2-difluoroacetophenone
Brand: ALDRICH

95%

Synonym(s):

2-Chloro-2,2-difluoro-1-phenylethanone, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacetophenone

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About This Item

Linear Formula:

C₆H₅COCF₂Cl

CAS Number:

384-67-8

Molecular Weight:

190.57

UNSPSC Code:

12352101

NACRES:

NA.22

PubChem Substance ID:

329768330

MDL number:

MFCD00042123

Beilstein/REAXYS Number:

2251448

Assay:

95%

Form:

liquid

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Properties

Quality Level

100

assay

95%

form

liquid

reaction suitability

reaction type: C-C Bond Formation

refractive index

n20/D 1.4954, n20/D 1.497 (lit.)

bp

94-96 °C/35 mmHg (lit.)

density

1.293 g/mL at 25 °C (lit.), 1.3178 g/mL at 25 °C

functional group

chloro, fluoro, ketone, phenyl

SMILES string

FC(F)(Cl)C(=O)c1ccccc1

InChI

1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H

InChI key

MNOONJNILVDLSW-UHFFFAOYSA-N

Description

General description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.

Application

2-Chloro-2,2-difluoroacetophenone can be used:

As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

160.0 °F

flash_point_c

71.1 °C

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

MKBS3273V

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Global Trade Item Number

SKU	GTIN
792373-1G	04061826183823
792373-10G	04061833332856