792373
2-Chloro-2,2-difluoroacetophenone
95%
Synonym(s):
2-Chloro-2,2-difluoro-1-phenylethanone, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacetophenone
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About This Item
Linear Formula:
C6H5COCF2Cl
CAS Number:
Molecular Weight:
190.57
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2251448
Assay:
95%
Form:
liquid
Quality Segment
assay
95%
form
liquid
reaction suitability
reaction type: C-C Bond Formation
refractive index
n
bp
94-96 °C/35 mmHg (lit.)
density
1.293 g/mL at 25 °C (lit.), 1.3178 g/mL at 25 °C
functional group
chloro, fluoro, ketone, phenyl
SMILES string
FC(F)(Cl)C(=O)c1ccccc1
InChI
1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChI key
MNOONJNILVDLSW-UHFFFAOYSA-N
General description
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.
Application
2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
160.0 °F
Flash Point (°C)
71.1 °C
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