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Sigma-Aldrich

Fluorescent nanodiamond

Nitrogen vacancy ~3ppm NV centers, 100 nm avg. part. size, 1 mg/mL in deionized water

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Synonym(s):
Diamond nanopowder, Nanodiamonds
Linear Formula:
C
NACRES:
NA.23

form

suspension

Quality Level

100

composition

Nitrogen vacancy, ~3ppm NV centers

concentration

1 mg/mL in deionized water

avg. part. size

100 nm

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General description

Fluorescent nanodiamonds (FNDs) can be prepared by subjecting synthetic diamond nanocrystallites to helium ions. FND is biocompatible and its surface can be easily functionalized. It is a very useful tool in bioimaging mainly because the photons emitted from the defect centers of FND upon laser excitation can easily penetrate the tissue. The emission from FNDs is extremely stable. The average size of the FNDs is 100 nm.
In fluorescent nanodiamonds, the nitrogen vacancy centers in the diamond lattice provide the fluorescence; unlike the quantum dots or organic dyes, the color centers in these don′t photobleach or photoblink. These outstanding properties of fluorescent nanodiamonds along with their biocompatibility, large surface area etc. make them promising bioimaging probes.
Product can be functionalized with carboxylic acid, hydroxyl, ketones, ethers, and/or hydrogen.

Application

Potential uses of FNDs are as in vivo nanoprobe for bioimaging, cell labelling and cell tracking.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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The Exocytosis of Fluorescent Nanodiamond and Its Use as a Long-Term Cell Tracker
Fang CY, et al.
Small, 7(23), 3363-3370 (2011)
Nanodiamonds for optical bioimaging
Y. Y. Hui, C-L Cheng, and H-C Chang
Journal of Physics D: Applied Physics, 43(37), 374021-374021 (2010)
Highly Fluorescent Nanodiamonds Protein-Functionalized for Cell Labeling and Targeting
B-M Chang, H-S Lin, L-J Su, et al.
Advances in Functional Materials, 23(46), 5737-5745 (2013)
Mass production and dynamic imaging of fluorescent nanodiamonds
Chang YR, et al.
Nature Nanotechnology, 3(5), 284-288 (2008)

Articles

Functionalization of Fluorescent Nanodiamonds for Bioimaging

Properties & characteristics of Fluorescent Nanodiamonds & biofunctionalization strategies explained. Conjugation protocols for streptavidin functionalization, biotinylation & coupling biotinylated/streptavidin provided. FNDs may be used for labeling of low-level expressed targets, Bioimaging & Bioconjugation.

Fluorescent Nanodiamond Particles: Properties and Applications

Fluorescent Nanodiamond Particles (FNDs)- Find properties and applications of nanodiamond particles.

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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