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Merck
CN

804371

Fro-DO, mixture of diastereomers

97%, powder

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About This Item

Empirical Formula (Hill Notation):
C24H22N2O6S2
Molecular Weight:
498.57
MDL number:
MFCD30343643
UNSPSC Code:
12161600
PubChem Substance ID:
329768865
NACRES:
NA.22

Key Documents

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Product Name

Fro-DO, mixture of diastereomers, 97%

SMILES string

O=C(N([C@H](C(C=CC=C1)=C1C2)[C@H]2C3)S3(=O)=O)/C=C/C(N4[C@H](C(C=CC=C5)=C5C6)[C@H]6CS4(=O)=O)=O

InChI

1S/C24H22N2O6S2/c27-21(25-23-17(13-33(25,29)30)11-15-5-1-3-7-19(15)23)9-10-22(28)26-24-18(14-34(26,31)32)12-16-6-2-4-8-20(16)24/h1-10,17-18,23-24H,11-14H2/b10-9+/t17-,18-,23+,24+/m1/s1

InChI key

CZVFUQRTDAQUQL-SKLQJEMHSA-N

assay

97%

form

powder

reaction suitability

core: nickel, reagent type: catalyst

Quality Level

100

Related Categories

Application

Enables the generation of quaternary centers by Ni-catalyzed cross coupling with aziridines.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Chung-Yang Dennis Huang et al.
Journal of the American Chemical Society, 137(17), 5638-5641 (2015-04-17)
A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and

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