808512
γ-[(Propargyl)-imido]-ATP sodium salt
Synonym(s):
Adenosine-5’-[γ-(propargyl)-imido]triphosphate sodium salt
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About This Item
Empirical Formula (Hill Notation):
C13H19N6O12P3 · xNa+
Molecular Weight:
544.24 (free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
Assay:
≥95% (HPLC)
Form:
solid
assay
≥95% (HPLC)
Quality Segment
form
solid
reaction suitability
reaction type: click chemistry
solubility
10 mM Tris-HCl, pH 7.5: soluble
shipped in
wet ice
storage temp.
−20°C
SMILES string
NC1=NC=NC2=C1N=CN2[C@H]3O[C@H](COP(OP(O)(OP(O)(NCC#C)=O)=O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C13H19N6O12P3/c1-2-3-18-32(22,23)30-34(26,27)31-33(24,25)28-4-7-9(20)10(21)13(29-7)19-6-17-8-11(14)15-5-16-12(8)19/h1,5-7,9-10,13,20-21H,3-4H2,(H,24,25)(H,26,27)(H2,14,15,16)(H2,18,22,23)/t7-,9-,10-,13?/m1/s1
InChI key
PIPOEUYSJJTELD-RJNFYWFKSA-N
Application
Lee, et al,. reported a non-radioactive version of in vitro phosphorylation where γ-[(Propargyl)-imido]-ATP (compound 1) was successfully used instead of γ-32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, alkyne-modified protein substrate can be labeled with azides of biotin or fluorescent dyes using Cu(I)-catalyzed click chemistry.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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