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809322

1-(2-Aminoethyl)maleimide hydrochloride

Name: 1-(2-Aminoethyl)maleimide hydrochloride
Brand: ALDRICH

Synonym(s):

1-(2-Aminoethyl)pyrrole-2,5-dione hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₉N₂O₂Cl

Molecular Weight:

176.60

UNSPSC Code:

12352111

PubChem Substance ID:

329769156

NACRES:

NA.22

MDL number:

MFCD09800491

Assay:

95%

Form:

powder

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Properties

assay

95%

Quality Level

100

form

powder

mp

166 °C

functional group

amine, imide, maleimide

SMILES string

Cl.N1(C(=O)C=CC1=O)CCN

InChI

1S/C6H8N2O2.ClH/c7-3-4-8-5(9)1-2-6(8)10;/h1-2H,3-4,7H2;1H

InChI key

NJQOCRDPGFWEKA-UHFFFAOYSA-N

Description

General description

1-(2-Aminoethyl)maleimide hydrochloride (N-(2-Aminoethyl)maleimide hydrochloride salt) can be prepared from tert-butyl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylcarbamate.

Application

1-(2-Aminoethyl)maleimide hydrochloride (1-(2-Aminoethyl)-1H-pyrrole-2,5-dione HCl salt) may be used in the preparation of N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD) and 4-nitrophenyl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylcarbamate.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides.

Pieter van der Veken et al.

Chembiochem : a European journal of chemical biology, 6(12), 2271-2280 (2005-10-29)

Gaining insight into phosphoproteomes is of the utmost importance for understanding regulation processes such as signal transduction and cellular differentiation. While the identification of phosphotyrosine-containing amino acid sequences in peptides and proteins is now becoming possible, mainly because of the

TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).

Yu Mizote et al.

Journal of dermatological science, 73(3), 209-215 (2013-12-10)

N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD) is a toxic tyrosinase substrate developed to treat melanoma. We investigated the effect of NPCMD on innate immune responses in monocytes. CD14⁺ monocytes and a monocytic cell line, THP-1, were stimulated with NPCMD in vitro. Cytokines in

Global Trade Item Number

SKU	GTIN
809322-100MG	04061833244036