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83060

tert-Butyl 12-amino-4,7,10-trioxadodecanoate

technical, ≥80% (T)

Synonym(s):

Amino-PEG3-tert-butyl ester, tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate

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About This Item

Empirical Formula (Hill Notation):
C13H27NO5
CAS Number:
252881-74-6
Molecular Weight:
277.36
NACRES:
NA.22
PubChem Substance ID:
57652942
UNSPSC Code:
12352200
MDL number:
MFCD06201017
Assay:
≥80% (T)
Form:
solid
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grade

technical

Quality Segment

100

assay

≥80% (T)

form

solid

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

SMILES string

CC(C)(C)OC(=O)CCOCCOCCOCCN

InChI

1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3

InChI key

CWFSAZJIJBTKRC-UHFFFAOYSA-N

Application

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:
  • Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
  • Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
  • Synthesis of polycationic adamantane-based dendrons for cell imaging.
  • Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

Other Notes

Intermediate in the synthesis of a spacer for combinatorial chemistry

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

337.5 °F

flash_point_c

169.7 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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