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83060

tert-Butyl 12-amino-4,7,10-trioxadodecanoate

Name: <I>tert</I>-Butyl 12-amino-4,7,10-trioxadodecanoate
Brand: ALDRICH

technical, ≥80% (T)

Synonym(s):

Amino-PEG3-tert-butyl ester, tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₂₇NO₅

CAS Number:

252881-74-6

Molecular Weight:

277.36

NACRES:

NA.22

PubChem Substance ID:

57652942

UNSPSC Code:

12352200

MDL number:

MFCD06201017

Assay:

≥80% (T)

Form:

solid

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Properties

grade

technical

Quality Level

100

assay

≥80% (T)

form

solid

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

SMILES string

CC(C)(C)OC(=O)CCOCCOCCOCCN

InChI

1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3

InChI key

CWFSAZJIJBTKRC-UHFFFAOYSA-N

Description

Application

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
Synthesis of polycationic adamantane-based dendrons for cell imaging.
Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

Other Notes

Intermediate in the synthesis of a spacer for combinatorial chemistry

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

337.5 °F

flash_point_c

169.7 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Phthalocyanine?peptide conjugates for epidermal growth factor receptor targeting.

Ongarora B G, et al.

Journal of Medicinal Chemistry, 55(8), 3725-3738 (2012)

Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor?Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope.

Keil S, et al.

Angewandte Chemie (International Edition in English), 40(2), 366-369 (2001)

Water soluble SERS labels comprising a SAM with dual spacers for controlled bioconjugation.

Jehn C, et al.

Physical Chemistry Chemical Physics, 11(34), 7499-7504 (2009)

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Global Trade Item Number

SKU	GTIN
83060-5G-F	04061833565322
83060-1G-F	04061826725146