900616
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine
≥95%
Synonym(s):
Iodo diazirine alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C7H9IN2
CAS Number:
Molecular Weight:
248.06
UNSPSC Code:
12352200
MDL number:
Product Name
3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine, ≥95%
assay
≥95%
form
liquid
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
Application
Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and iodine synthetic handle. When appended to a ligand or pharmacophore through its iodinated linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Other Notes
Technology Spotlight: Trifuctional Probe Building Blocks
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In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors
"Minimalist" Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling
Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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