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900657

Methoxy poly(ethylene glycol)-b-poly(D,L-lactide)

Name: Methoxy poly(ethylene glycol)-<I>b</I>-poly(<SC>D</SC>,<SC>L</SC>-lactide)
Brand: ALDRICH

2k-5k

Synonym(s):

mPEG-b-PLA, mPEG-PLA

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About This Item

Linear Formula:

HO[CH(CH₃)COO]_m[CH₂CH₂O]_nCH₃

NACRES:

NA.23

UNSPSC Code:

12162002

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Properties

Quality Level

100

form

powder or chunks

mol wt

PDLLA average M_n ~5,000, PEG average M_n ~2,000

storage temp.

2-8°C

Description

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide) (PLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Polymeric Micelles of PEG-PLA Copolymer as a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic Cancer.

Zahra Daman et al.

Pharmaceutical research, 32(11), 3756-3767 (2015-08-01)

Resistance to gemcitabine in pancreatic cancer (PC) may account for the failure of conventional treatments. Recently, salinomycin (SAL) has been identified as selective inhibitor of cancer stem cells (CSCs). In our study, we aimed to deliver SAL to gemcitabine-resistant PC

Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs.

Ho-Chul Shin et al.

Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294-300 (2009-05-05)

Current clinical and preclinical anticancer formulations are limited by their use of toxic excipients and stability issues upon combining different drug formulations. We have found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically

Octreotide-modified polymeric micelles as potential carriers for targeted docetaxel delivery to somatostatin receptor overexpressing tumor cells.

Yuan Zhang et al.

Pharmaceutical research, 28(5), 1167-1178 (2011-02-23)

Somatostatin analogue octreotide (OCT)-modified PEG-b-PLA micelles were constructed to bind to somatostatin receptors (SSTRs) overexpressed on tumor cells for enhanced intracellular drug delivery and improved therapeutic efficacy for malignant tumors. Copolymers conjugated with octreotide (OCT-PEG₆₀₀₀-b-PLA₅₀₀₀) were synthesized. The fluorescent probe

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Global Trade Item Number

SKU	GTIN
900657-500MG	04061833250709