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900659

Methoxy poly(ethylene glycol)-b-poly(D,L-lactide)

Name: Methoxy poly(ethylene glycol)-<I>b</I>-poly(<SC>D</SC>,<SC>L</SC>-lactide)
Brand: ALDRICH

5k-10k

Synonym(s):

mPEG-b-PLA, mPEG-PLA

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About This Item

Linear Formula:

HO[CH(CH₃)COO]_m[CH₂CH₂O]_nCH₃

NACRES:

NA.23

UNSPSC Code:

12162002

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Properties

Quality Level

100

form

solid

storage temp.

2-8°C

Description

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide) (PLA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Polymeric Micelles of PEG-PLA Copolymer as a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic Cancer.

Zahra Daman et al.

Pharmaceutical research, 32(11), 3756-3767 (2015-08-01)

Resistance to gemcitabine in pancreatic cancer (PC) may account for the failure of conventional treatments. Recently, salinomycin (SAL) has been identified as selective inhibitor of cancer stem cells (CSCs). In our study, we aimed to deliver SAL to gemcitabine-resistant PC

Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs.

Ho-Chul Shin et al.

Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294-300 (2009-05-05)

Current clinical and preclinical anticancer formulations are limited by their use of toxic excipients and stability issues upon combining different drug formulations. We have found that poly(ethylene glycol)-block-poly(d,l lactic acid) (PEG-b-PLA) micelles can deliver multiple poorly water-soluble drugs at clinically

Targeted polymeric micelle system for delivery of combretastatin A4 to tumor vasculature in vitro.

Yiguang Wang et al.

Pharmaceutical research, 27(9), 1861-1868 (2010-06-19)

To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent. CA4-loaded micelles were prepared from poly (ethylene glycol)-b-poly (d, l-lactide) copolymers. RGD peptides that target integrins alphavbeta3 and alphavbeta5, markers of angiogenic

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Global Trade Item Number

SKU	GTIN
900659-500MG	04061833250723