900660
Poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide)
5k-2k-5k
Synonym(s):
PLA-PEG-PLA, PLA-PEG-PLA triblock copolymer
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About This Item
Linear Formula:
HO(CH(CH3)COO)m(CH2CH2O)n(COCH(CH3)O)mH
UNSPSC Code:
12162002
form
solid
storage temp.
2-8°C
Application
Biocompatible, amphiphilic triblock polymer composed of a hydrophilic, central PEG block and two terminal hydrophobic poly(D,L-lactide) (PLA) blocks. These materials have been used in controlled release formulation and nanoparticle formation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kun Shi et al.
Scientific reports, 6, 19077-19077 (2016-01-12)
In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed and a systematic evaluation of the thermogelling system both in vitro and in vivo was performed. The aqueous PDLLA-PEG-PDLLA solutions above a critical gel concentration could
Mesoscale simulation and experimental studies of self-assembly behavior of a PLA-PEG-PLA triblock copolymer micelle for sustained drug delivery.
Chansuna M, et al.
Journal of Polymer Research, 21(6), 452-452 (2014)
H Danafar et al.
Pharmaceutical development and technology, 22(8), 947-957 (2016-01-08)
A conjugate of the antihypertensive drug, lisinopril, with triblock poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) copolymer was synthesized by the reaction of PLA-PEG-PLA copolymer with lisinopril in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugated copolymer was characterized in vitro by
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