Key Documents

900664

Poly(D,L-lactide-co-glycolide)(50:50)-b-poly(ethylene glycol)

Name: Poly(<SC>D</SC>,<SC>L</SC>-lactide-<I>co</I>-glycolide)(50:50)-<I>b</I>-poly(ethylene glycol)
Brand: ALDRICH

10k-2k

Synonym(s):

PLGA-b-PEG, PLGA-PEG

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About This Item

Linear Formula:

H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃

NACRES:

NA.23

UNSPSC Code:

12162002

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Properties

Quality Level

100

form

chunks

storage temp.

2-8°C

Description

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic poly(D,L-lactide-co-glycolide) (PLGA) block. These materials have been used in control release and nanoparticle formulation for drug encapsulation and delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

MKCS7450

MKCF1600

MKCG0738

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Articles

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation.

Fabienne Danhier et al.

Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)

The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.

Miles A Miller et al.

Nature communications, 6, 8692-8692 (2015-10-28)

Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their

Polymer degradation and drug delivery in PLGA-based drug-polymer applications: A review of experiments and theories.

Yihan Xu et al.

Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)

Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact

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Global Trade Item Number

SKU	GTIN
900664-500MG	04061833250778