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900671

Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

Name: Methoxy poly(ethylene glycol)-<I>block</I>-poly(ε-caprolactone)
Brand: ALDRICH

5k-2k

Synonym(s):

mPEG-b-PCL, mPEG-PCL

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About This Item

Linear Formula:

CH₃O(CH₂CH₂O)_n(COCH₂CH₂CH₂CH₂CH₂O)_mH

NACRES:

NA.23

UNSPSC Code:

12162002

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Properties

Quality Level

100

form

powder

mol wt

PCL average M_n ~2,000, PEG average M_n ~5,000

transition temp

flash point >230 °F, T_m 54-57 °C

storage temp.

2-8°C

Description

Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These materials have been used as a block copolymer surfactant as well as in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Articles

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

In vitro evaluation of cenderitide-eluting stent I -an antirestenosis and proendothelization approach.

Xu Wen Ng et al.

Journal of pharmaceutical sciences, 103(11), 3631-3640 (2014-09-17)

Despite the success that drug-eluting stents (DESs) have achieved for minimizing in-stent restenosis (ISR), the antirestenotic agents used in DES have been implicated in delayed endothelial healing and impairment of endothelial functions. Cenderitide (CD-NP) is a novel antiproliferation chimeric peptide

A biodegradable ocular implant for long-term suppression of intraocular pressure.

Xu Wen Ng et al.

Drug delivery and translational research, 5(5), 469-479 (2015-06-24)

Timolol maleate (TM) has been used for many years for the reduction of intraocular pressure (IOP) in glaucoma patients. However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage

On the mechanism of formation of vesicles from poly(ethylene oxide)-block-poly(caprolactone) copolymers.

Adams DJ, et al.

Soft Matter, 5, 3086-3096 (2009)

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Global Trade Item Number

SKU	GTIN
900671-500MG	04061833250808