900862
(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol
Synonym(s):
Hydroxyl diazirine TMS-alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C14H15F3N2OSi
CAS Number:
Molecular Weight:
312.36
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
powder or crystals
SMILES string
OCC1=CC=C(C2(N=N2)C(F)(F)F)C=C1C#C[Si](C)(C)C
assay
≥95%
form
powder or crystals
storage temp.
−20°C
Application
(4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)-2-((trimethylsilyl)ethynyl)phenyl)methanol is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
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