900893
L-Homopropargylglycine hydrochloride
Synonym(s):
HPG
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About This Item
Empirical Formula (Hill Notation):
C6H9NO2 · HCl
CAS Number:
Molecular Weight:
163.60
NACRES:
NA.22
UNSPSC Code:
12352209
Form:
powder or crystals
form
powder or crystals
availability
available only in USA
mp
162 °C
storage temp.
−20°C
SMILES string
O=C(O[H])[C@@](C([H])([H])C([H])([H])C#C[H])([H])N([H])[H].Cl[H]
InChI
1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
InChI key
SCGJGNWMYSYORS-UHFFFAOYSA-N
Application
L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety. This compound can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne. For example the alkyne-modified protein can be detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS/MS and MALDI-MS analysis.
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis
Tsai Y C, et al.
Molecular and Cellular Proteomics, 13(1), 73-83 (2014)
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering.
Wei L, et al.
Nature Methods, 11(4), 410-410 (2014)
Cell-free production of Gaussia princeps luciferase?antibody fragment bioconjugates for ex vivo detection of tumor cells.
Patel K G, et al.
Biochemical and Biophysical Research Communications, 390(3), 971-976 (2009)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 900893-100MG | 04061833251379 |