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901215

Ephos

Name: Ephos
Brand: ALDRICH

≥95%, powder or crystals

Sustainability features

Synonym(s):

Dicyclohexyl(3-isopropoxy-2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphane

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₅₅OP

CAS Number:

2118959-55-8

Molecular Weight:

534.80

MDL number:

MFCD31619192

UNSPSC Code:

12352128

NACRES:

NA.22

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Properties

Product Name

Ephos, ≥95%

Quality Segment

100

product line

Buchwald Ligand

assay

≥95%

form

powder or crystals

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: catalyst
reaction type: Cross Couplings, reagent type: ligand

greener alternative product score

old score: 41
new score: 28
Find out more about DOZN™ Scoring

sustainability

Sustainability features

mp

161-162 °C

functional group

phosphine

greener alternative category

SMILES string

P(C4CCCCC4)(C3CCCCC3)c1c(cccc1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC(C)C

InChI

1S/C36H55OP/c1-24(2)28-22-32(25(3)4)35(33(23-28)26(5)6)31-20-15-21-34(37-27(7)8)36(31)38(29-16-11-9-12-17-29)30-18-13-10-14-19-30/h15,20-27,29-30H,9-14,16-19H2,1-8H3

InChI key

FDAKNRLXSJBEFL-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products that adhere to one of the four categories of Greener Alternatives. This product belongs to the category of Re-engineered Products, demonstrating key improvements in Green Chemistry Principles such as "Atom Economy", "Safer Solvents and Auxiliaries", and "Inherently Safer Chemistry for Accident Prevention". Click here to view its DOZN scorecard.

Application

Ephos can be used as a ligand in the palladium-catalyzed synthesis of 4-arylaminothiazoles and 2-arylaminooxazoles.

Buchwald ligand for Pd-catalyzed C–N cross-coupling between primary amines and aryl
halides to form 2-arylaminooxazoles. Catalyst system was reported with NaOPh (CDS001581).

Other Notes

Mechanistic Insight Leads to a Ligand That Facilitates the Pd-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)