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901404

Poly(ethylene glycol) linear dendron

NHBoc terminated, PEG Mn 2000, generation 2

Synonym(s):

Dendron functionalized PEG, PFD-G2-PEG2k-NHBoc

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About This Item

Empirical Formula (Hill Notation):
C138H260N4O67
Molecular Weight:
3047.53
UNSPSC Code:
51171641
NACRES:
NA.23
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form

solid

mol wt

PEG Mn 2000

color

white to off-white

storage temp.

−20°C

SMILES string

CC(COC(CCNC(OC(C)(C)C)=O)=O)(C(OCC(C(OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)(C)COC(C(COC(CCNC(OC(C)(C)C)=O)=O)(C)COC(CCNC(OC(C)(C)C)=O)=O)=O)=O)COC(CCNC(

General description

  • Polymer architecture: PEG-linear dendron
  • Generation: 2
  • PEG average Mn: 2,000
  • End group functionality: Boc-protected amine
  • No. surface groups: 4
  • Calculated mol. wt.: 3031.56 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrons feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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