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Merck
CN

902268

seMpai

Synonym(s):

DP3-Na, TokeOni analogue, water-soluble NIR emission luciferin analogue, 2-[(1E,3E)-6-[3-(dimethylamino)pyridine]-1,3-butadien-1-yl]-4,5-dihydro-(4S)-4-thiazolecarboxylic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C15H16N3NaO2S
Molecular Weight:
325.36
NACRES:
NA.23
UNSPSC Code:
12352106
Form:
powder
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description

Purity: mixture of D (80% min.) and L (20% max.) forms

form

powder

color

black to yellow-brown

storage temp.

−20°C

General description

seMpai (DP3-Na) is a cutting-edge near-infrared (NIR) emission luciferin analogue with enhanced solubility in water, making it ideal for bioimaging applications. This compound exhibits a luminescence peak at 670-680 nm, facilitating high-sensitivity imaging in biological research. As a luciferin analogue, seMpai provides a vital tool for studying bioluminescent phenomena in living organisms.


Preparation Notes:

Storage Conditions: Store at @20°C to maintain stability and efficacy.

Handling Precautions: Use appropriate personal protective equipment (PPE) during handling. Ensure a well-ventilated area to avoid inhalation of dust.

Application

Applications:
  • Bioimaging
  • In vivo imaging

Features and Benefits

  • Enhanced Solubility: The water-soluble nature of seMpai allows for greater versatility in experimental setups, making it suitable for a wide range of biological applications.
  • High Sensitivity: With a luminescence peak in the near-infrared range, seMpai enables high-sensitivity imaging for in vivo studies, enhancing the detection of biological processes.
  • Scalable Research Applications: Ideal for both small-scale studies and larger research projects, seMpai supports scalable applications in bioimaging and related fields


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Articles

Bioluminescence imaging (BLI) systems allows for high-sensitive and noninvasive monitoring of cell proliferation, activity of signaling pathways and protein-protein interactions in living tissues.

seMpai substrate is suitable for near-infrared BLI in biological experiments, offering high solubility for extended bioluminescent applications.

Graphene nanoribbons (GNRs) are quasi-one-dimensional narrow strips of graphene comprised of sp2-hybridized carbon atoms arranged into hexagonal honeycomb lattice configurations.

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Quantum yield improvement of red-light-emitting firefly luciferin analogues for in vivo bioluminescence imaging
Kiyama M, et al.
Tetrahedron, 74(6), 652- 660 (2018)
Synthesis and Luminescence Properties of Near-Infrared N-Heterocyclic Luciferin Analogues for In Vivo Optical Imaging.
Saito R, et al.
Bulletin of the Chemical Society of Japan, 92(3), 182-8585 (2018)
Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging.
Fukuchi M, et al.
Molecular Brain, 13(1), 122-122 (2020)



Global Trade Item Number

SKUGTIN
902268-5MG04061838635563
902268-1MG04061838635556