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910791

Poly(ethylene glycol)-block-polyethyleneimine

Name: Poly(ethylene glycol)-<I>block</I>-polyethyleneimine
Brand: ALDRICH

PEG M_n 750, PEI M_n 15k

Synonym(s):

Linear poly(ethylene glycol)-block-polyethylenimine, Nanopatterning, PEG-b-PEI, PEG-PEI, block-copolymers

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About This Item

Linear Formula:

CH₃(C₂H₄O)_m(C₂H₅N)_nOH

NACRES:

NA.23

UNSPSC Code:

12162002

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Properties

form

powder or solid

mol wt

PEG M_n 750, PEG M_w 750 Da, PEI M_n 15k, PEI M_w 10,000 Da

color

white to pale yellow

storage temp.

2-8°C

Description

Application

Gene therapy using polymeric nonviral vectors promises considerable advances in the treatment of many genetic and acquired diseases due to the carrier safety and low immunogenicity profiles. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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