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Merck
CN

911690

C5 Lenalidomide

≥95%

Synonym(s):

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC® research

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About This Item

Empirical Formula (Hill Notation):
C13H13N3O3
CAS Number:
191732-70-4
Molecular Weight:
259.26
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
MFCD31692701

Key Documents

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Product Name

C5 Lenalidomide, ≥95%

InChI

1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)

InChI key

WLUIQUZGNPAKRL-UHFFFAOYSA-N

SMILES string

NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1

ligand

C5 Lenalidomide

assay

≥95%

form

powder

reaction suitability

reagent type: ligand

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2

target_organs

Blood

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000375893
0000375893
MKCM1381

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Articles

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

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