911798
N-(4-Bromophenyl)-N-phenylacrylamide
≥95%
别名:
Electrophilic scout fragment, KB05, Scout fragment for targetable cysteine
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关于此项目
经验公式（希尔记法）:
C15H12BrNO
化学文摘社编号:
分子量:
302.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
(Powder or crystals or solid or chunks)
Quality Segment
assay
≥95%
form
(Powder or crystals or solid or chunks)
storage temp.
2-8°C
SMILES string
Brc1ccc(cc1)N(c2ccccc2)C(=O)C=C
InChI
1S/C15H12BrNO/c1-2-15(18)17(13-6-4-3-5-7-13)14-10-8-12(16)9-11-14/h2-11H,1H2
InChI key
WFQQVUPOAKOTGT-UHFFFAOYSA-N
Application
N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile, or ″scout″ fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
11 - Combustible Solids
wgk
WGK 3