Skip to Content
Merck
CN

914223

Biotin-SLF

Synonym(s):

(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC® and targeted protein degradation research

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C52H76N6O13S
CAS Number:
2230857-85-7
Molecular Weight:
1025.26
MDL number:
MFCD33021721
UNSPSC Code:
12352200
NACRES:
NA.22

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

QFIMAWUXIBINCP-SLBVAARVSA-N

SMILES string

O=C(CCC(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)NC3=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC=C(OC)C(OC)=C5)=CC=C3

ligand

biotin

form

powder

storage temp.

−20°C

Quality Level

100

Related Categories

Application

Biotin-SLF (bio-SLF) is an FKBP12WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.


Related tools:
Additional bifunctional tools for FKPB12 variants:

  • dTAG-13 (SML2601) for FKBP12F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
  • Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Behnam Nabet et al.
Nature chemical biology, 14(5), 431-441 (2018-03-28)
Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the requisite delay between modulation to experimental measurement. To enable the

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service