920045
Low endotoxin GelMA
mol wt 95 kDa, degree of substitution 60%
Synonym(s):
GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
Quality Level
form
powder
mol wt
95 kDa
impurities
≤10 EU/g Endotoxin
color
white to off-white
storage temp.
2-8°C
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Application
This product is low endotoxin version GelMA and ready to be used in biomedical applications. The bloom number is ∼170.
GelMA can be used to form hydrogels for tissue engineering and 3D bioprinting. Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
GelMA can be used to form hydrogels for tissue engineering and 3D bioprinting. Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Packaging
1g in bottle
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Xin Zhao et al.
Advanced healthcare materials, 5(1), 108-118 (2015-04-17)
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In
Preparation and characterization of gelatin-poly(methacrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for glipizide.
Gupta NV, et al.
Indian Journal of Pharmaceutical Sciences, 69(1), 64-68 (2007)
Mehdi Nikkhah et al.
Biomaterials, 33(35), 9009-9018 (2012-09-29)
Engineering of organized vasculature is a crucial step in the development of functional and clinically relevant tissue constructs. A number of previous techniques have been proposed to spatially regulate the distribution of angiogenic biomolecules and vascular cells within biomaterial matrices
Jason W Nichol et al.
Biomaterials, 31(21), 5536-5544 (2010-04-27)
The cellular microenvironment plays an integral role in improving the function of microengineered tissues. Control of the microarchitecture in engineered tissues can be achieved through photopatterning of cell-laden hydrogels. However, despite high pattern fidelity of photopolymerizable hydrogels, many such materials
Heemin Kang et al.
Acta biomaterialia, 10(12), 4961-4970 (2014-08-26)
Human induced pluripotent stem cells (hiPSC) are a promising cell source with pluripotency and self-renewal properties. Design of simple and robust biomaterials with an innate ability to induce lineage-specificity of hiPSC is desirable to realize their application in regenerative medicine.
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