Natural Polymers

Two green leaves with molecular structures on them.

Natural polymers are extracted from natural sources and include protein (gelatin), polysaccharides (cellulose and chitin), and lignins. These polymers can be modified by adding other functional groups to form functionalized polymers, such as TissuFab^® brand, with low endotoxicity and bioburden levels. They are used in controlled drug delivery and pharmaceutical formulations, tissue engineering, regenerative medicine, wound care, and medical device manufacturing.

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Polysaccharides

PRONOVA^® alginates:

PRONOVA^® alginates are high-purity sodium alginates composed of guluronate or mannuronate monomer units. Products such as PRONOVA^® UP VLVG and PRONOVA® UP VLVM are widely used for the encapsulation of living cells and therapeutic proteins in cell therapy medications, cryoprotectant, bone putty binder for tissue engineering, 3D bioprinting, foams and cell tissue scaffolds, hydrogels, advanced drug delivery systems, implants, wound management, and medical devices.

ProtaSea^® Fucoidan

ProtaSea^® Fucoidan is a fucose-rich polysaccharide extracted from the brown seaweed Laminaria Hyperborea. These fucoidans are used in personal care and nutraceutical products, as well as in drug therapy research, joint health, immune support, anti-inflammatory therapies, and medical device coatings.

Proteins

Novatach™ LVM GRGDSP Peptides

Novatach™ peptides are bioactive peptides conjugated to high molecular weight sodium alginate, either mannuronate or guluronate. Peptides such as Novatach^™ LVM GRGDSP and Novatach^™ VLVG GRGDSP promotes interaction between cells and alginate-based scaffolds and matrices. These peptides act as initiators of biological interactions between alginate hydrogels and cells, supporting applications such as cell encapsulation and the delivery of therapeutic proteins for cell therapy.

Mytilus edulis foot protein-1 (MEFP-1)

MEFP-1 is a bioadhesive protein derived from the marine mussel Mytilus edulis. MEFP-1 coatings are used in a variety of applications, including in situ hybridization, immunohistochemistry, tissue engineering, drug delivery, ELISA, microfluidics, microinjection, and various microscopy techniques.

Hyaluronic acid adipic dihydrazide (HA-ADH)

Hyaluronic acid adipic dihydrazide is used to form hydrogels for applications ranging from tissue engineering and regeneration to drug delivery and bioinks for 3D bioprinting.

Lignins

Lignin alkali and Lignosulfonic acid sodium salt are used as dispersing agent in a variety of applications, including dyestuffs, wax emulsions, pigments, water treatment, cleaning formulations, and agricultural chemicals.

Gelatins

Silk Fibroin:

Silk fibroin is a natural polymer composed of fibroin and sericin proteins. It is used in various bioprinting techniques, including inkjet, extrusion-based, laser-assisted, and DLP bioprinting, for tissue engineering applications.

Cellulose

Hydroxypropyl cellulose is used as a thermos-responsive aqueous foam, a corrosion inhibitor, and in orally disintegrating films. Cellulose-based materials are also used in sensors, actuators, hygienic products, and in agricultural applications, such as pesticide carriers, water reservoir, and for soil water retention.

Chitosans:

Chitosans are used as flocculants, encapsulating agents, in protein precipitation, and as aqueous thickener.

TissueFab^® Polymers

TissueFab^® Polymers are ready-to-use formulations optimized for high printing fidelity and cell viability, helping eliminate the lengthy bioink formulation development process. They are supplied with step-by-step protocols developed and tested by our 3D Bioprinting Scientists, ensuring reliability and ease of use. These formulations are compatible with various extrusion-based 3D bioprinter models and feature rapid, cell-friendly curing methods. Additionally, users can benefit from advanced support provided by our Project Management and Research Development teams.

TissueFab^®Discrete GelMA

TissueFab^® Discrete GelMA is used in 3D-bioprinting, tissue engineering, regenerative medicine, as well as in drug and cell delivery and surface coatings.

TissueFab^®Bioink:

TissueFab^® bioink and TissueFab^® GelAlg − LAP are gelatin methacrylate-alginate compounds that are ready-to-use, low-endotoxin bioinks designed for 3D-bioprinting applications.

Functionalized TissueFab^®

TissueFab^® tyramine functionalized poly(amino acid) and TissueFab^® norbornene functionalized poly(amino acid) are used as bioink precursors in tissue engineering and hydrogel formation.

TissueFab^® porous bioink kit

TissueFab^® Porous Bioink Kits are specifically designed for bioprinting porous, cell-laden hydrogels in customizable shapes, eliminating the need for supporting materials. These kits play an important role in regenerative medicine and tissue engineering, particularly in applications requiring a high degree of cell infiltration and vascularization. They are utilized in cartilage and bone tissue engineering, skin modeling and regeneration, wound repair, muscle tissue engineering, and in the development of vascularized tissues and blood vessels.

Functionalized Polymers

Functionalized Alginates:

mPEG functionalized alginate is used to adjust the stress relaxation behavior of alginate hydrogels and to create microparticles with enhanced mechanical properties.

Functionalized Heparin:

Heparin methacrylate is a functionalized natural polymer used in drug delivery, 3D bioprinting, and tissue engineering applications.

Functionalized Gelatins:

mPEG functionalized gelatin, Azide functionalized gelatin and Thiol functionalized gelatin are used in drug delivery, tissue engineering, and 3D bioprinting applications.

Functionalized Hyaluronic Acid

Aldehyde functionalized hyaluronic acid enables reductive coupling with primary amines, providing a versatile platform for a wide range of chemical modifications across various applications.

Low Endotoxin, Ready-to-Use Natural Polymers:

Low-endotoxin polymers improve biocompatibility and minimize immune and inflammatory responses. These formulations aid in preserving the structural integrity of printed tissues while ensuring durability in physiological conditions. They are produced through tightly controlled and reproducible processes to ensure consistent quality across batches.

Low endotoxin, sterile and ready-to-use Alginate Solution:

Alginate solution is a medium-viscosity formulation widely used for fabricating tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug and gene delivery.

Low Endotoxin Gelatins:

Low endotoxin gelatin solution is sterile, ready-to-use solution used in tissue engineering and 3D bioprinting. Both low endotoxin gelatin from porcine skin (X-Pure^® 10P HBLV) and low endotoxin gelatin from bovine bone are utilized in highly purified biomaterials, including hemostatic products, parenteral formulations (such as vaccines), and regenerative medicine.

Low Endotoxin and Bioburden Collagen:

Ovine collagen is used in 3D bioprinting, tissue engineering, drug delivery, and regenerative medicine, as well as in applications related to cell culture, cell encapsulation, expansion, and differentiation.