920495
2-(6-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazin-2-yl)acetic acid
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C14H19N3O4
Molecular Weight:
293.32
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
form
powder
Quality Level
reaction suitability
reagent type: linker
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CC(C2=CN=CC(CC(O)=O)=N2)C1)=O)C
InChI
1S/C14H19N3O4/c1-14(2,3)21-13(20)17-7-9(8-17)11-6-15-5-10(16-11)4-12(18)19/h5-6,9H,4,7-8H2,1-3H3,(H,18,19)
InChI key
AIWAVIOLLBXRFG-UHFFFAOYSA-N
Application
2-(6-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazin-2-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920487
920576
920584
ADV638390284
Similar linkers in this series:
920487
920576
920584
ADV638390284
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
wgk
WGK 3
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 920495-50MG | 04065266025491 |