920568
tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C13H21N3O2
Molecular Weight:
251.32
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
reaction suitability
reagent type: linker
Quality Level
functional group
ester
storage temp.
2-8°C
SMILES string
CC(C)(OC(CCC1=CN=C2CNCCN12)=O)C
InChI key
OKFDKTIPEQWBHV-UHFFFAOYSA-N
Application
tert-Butyl 3-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424
Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 920568-50MG | 04065266033069 |
| 920568-100MG | 04065266033052 |