About This Item
ligand
VL285 phenol
Quality Level
form
solid
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4O
InChI
1S/C29H32N4O5S/c1-16(2)25(33-13-20-6-4-5-7-22(20)28(33)37)29(38)32-14-21(34)11-23(32)27(36)30-12-19-9-8-18(10-24(19)35)26-17(3)31-15-39-26/h4-10,15-16,21,23,25,34-35H,11-14H2,1-3H3,(H,30,36)/t21-,23+,25+/m1/s1
InChI key
KNZQRBRUYSXXRG-VTZPFEBOSA-N
Related Categories
Application
(S,R,S)-VL285 Phenol-linker conjugates are also available for synthesis of degraders. Browse our full offering of degrader building blocks that streamlines the synthesis of degrader libraries.
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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