923389
1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C18H30N2O5
Molecular Weight:
354.44
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
InChI key
CVHPZSHLWZEYQS-UHFFFAOYSA-N
SMILES string
O=C(O)C(CC1)CCN1CC(CC2)OC32CN(C(OC(C)(C)C)=O)C3
form
powder or crystals
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
Quality Level
Related Categories
Application
1-((2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octan-6-yl)methyl)piperidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Other Notes
Legal Information
Practum is a registered trademark of Sartorius Lab Instruments GmbH & Co. KG
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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