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925012

E7820-PEG5-NH2 hydrochloride

Synonym(s):

N-(17-amino-3,6,9,12,15-pentaoxaheptadecyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, DCAF15 protein degrader building block

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About This Item

Empirical Formula (Hill Notation):
C29H39N5O8S · xHCl
Molecular Weight:
617.71 (free base basis)
NACRES:
NA.22
UNSPSC Code:
12352200
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ligand

E7820

Quality Level

100

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

Application

Protein degrader builiding block E7820-PEG5-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Protein Degrader Building Blocks

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000142973
0000139169

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Global Trade Item Number

SKUGTIN
925012-50MG04065267409634