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925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Name: 4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine
Brand: ALDRICH

Synonym(s):

2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₂O₃S

CAS Number:

2429964-95-2

Molecular Weight:

214.24

MDL number:

MFCD16251316

NACRES:

NA.22

UNSPSC Code:

12352200

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Properties

reaction suitability

reagent type: chemical modification reagent

Quality Segment

100

storage temp.

2-8°C

Description

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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