927295
Linear polyethylenimine-block-poly(ethylene glycol)
PEG average Mn 2,000, PEI average Mn 10,000
Synonym(s):
Nanopatterning, PEG-b-PEI, PEG-PEI, Poly(ethylene glycol)-block-polyethylenimine, block-copolymers
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About This Item
Linear Formula:
CH3(C2H4O)n(C2H5N)mOH
NACRES:
NA.25
UNSPSC Code:
12162002
form
powder or solid
Quality Segment
mol wt
PEG Mn 2,000 Da, PEG average Mn 2,000, PEI Mn 10,000 Da, PEI average Mn 10,000
color
white to pale yellow
storage temp.
2-8°C
Application
Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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