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Merck
CN

928380

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid

≥95%

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About This Item

Empirical Formula (Hill Notation):
C18H29N5O5
Molecular Weight:
395.45
NACRES:
NA.22
UNSPSC Code:
12352106
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Quality Segment

assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

Boc, amine, carboxylic acid

storage temp.

2-8°C

Application

5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Global Trade Item Number

SKUGTIN
928380-100MG04065268237786
928380-250MG04065268237793