929476
N-Acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine
≥95%
Synonym(s):
p-Fluorobenzylguanine ligand, AUTAC ligand, FBnG
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About This Item
Empirical Formula (Hill Notation):
C17H17FN6O4S
CAS Number:
Molecular Weight:
420.42
UNSPSC Code:
12352209
NACRES:
NA.21
MDL number:
Quality Segment
assay
≥95%
form
powder or chunks
reaction suitability
reagent type: ligand
storage temp.
2-8°C
SMILES string
O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(O)=O)NC(C)=O)N2CC3=CC=C(C=C3)F
Application
N-acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine is a p-fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
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Other Notes
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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