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Merck
CN

930210

N-(2,5-Dichlorobenzoyl)glycyl-L-leucine

≥95.0%

Synonym(s):

(2S)-2-{2-[(2,5-Dichlorophenyl)formamido]acetamido}-4-methylpentanoic acid, CANDDY_MLN Tag

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About This Item

Empirical Formula (Hill Notation):
C15H18Cl2N2O4
CAS Number:
1824976-81-9
Molecular Weight:
361.22
UNSPSC Code:
12352209
NACRES:
NA.22

Key Documents

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Product Name

N-(2,5-Dichlorobenzoyl)glycyl-L-leucine, ≥95.0%

InChI

1S/C15H18Cl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12H,5,7H2,1-2H3,(H,18,21)(H,19,20)(H,22,23)/t12-/m0/s1

InChI key

DNIFDGIEBFRALC-LBPRGKRZSA-N

SMILES string

ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)=C1

assay

≥95.0%

form

powder

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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