930806
7-Octynoic acid, 8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]
≥95.0%
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About This Item
Empirical Formula (Hill Notation):
C21H22N2O5
CAS Number:
Molecular Weight:
382.41
UNSPSC Code:
12352106
MDL number:
Quality Segment
assay
≥95.0%
form
powder
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(O)CCCCCC#CC1=CC=CC=2C(=O)N(CC12)C3C(=O)NC(=O)CC3
InChI key
UYYFKFKQSNARRT-UHFFFAOYSA-N
Application
7-Octynoic acid, 8-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl] is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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