934224
NanoFabTx™- RGD Lipid Mix
for synthesis of RGD-functionalized liposomes
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
storage temp.
−20°C
Application
NanoFabTx™ RGD Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing RGD functionalized liposomes or lipid nanoparticles. RGD is a peptide composed of arginine, glycine, and aspartic acid (Arg-Gly-Asp).
RGD has high affinity to integrins (including alpha V beta 3) which are overexpressed on cancer cells such as glioma, ovarian cancer, breast cancer, pancreatic cancer to name a few. RGD conjugated lipids can be used to prepare liposomes to achieve targeted delivery of the anti-cancer agents to the cells which overexpress these receptors. The cells will internalize the RGD containing peptide via integrin-mediated endocytosis. As a result, the targeted liposomes avoid off target effects, a major side effect of many cancer therapies.
The RGD-functionalized liposomes synthesized from the NanoFabTx™ RGD Lipid Mix enable users to 1) encapuslate a wide variety of small molecules and 2) selectively target cells which overexpress RGD-binding integrins, such as cancer cells, without the need for lengthy trial-and-error optimization.
RGD has high affinity to integrins (including alpha V beta 3) which are overexpressed on cancer cells such as glioma, ovarian cancer, breast cancer, pancreatic cancer to name a few. RGD conjugated lipids can be used to prepare liposomes to achieve targeted delivery of the anti-cancer agents to the cells which overexpress these receptors. The cells will internalize the RGD containing peptide via integrin-mediated endocytosis. As a result, the targeted liposomes avoid off target effects, a major side effect of many cancer therapies.
The RGD-functionalized liposomes synthesized from the NanoFabTx™ RGD Lipid Mix enable users to 1) encapuslate a wide variety of small molecules and 2) selectively target cells which overexpress RGD-binding integrins, such as cancer cells, without the need for lengthy trial-and-error optimization.
Features and Benefits
- A ready-to-use lipid blend for the synthesis of RGD targeted liposomes
- Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- RGD ligand enables targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
For more information, please refer to the protocol under the Protocol section of this page.
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service