质量水平
储存温度
−20°C
应用
NanoFabTx™ RGD Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing RGD functionalized liposomes or lipid nanoparticles. RGD is a peptide composed of arginine, glycine, and aspartic acid (Arg-Gly-Asp).
RGD has high affinity to integrins (including alpha V beta 3) which are overexpressed on cancer cells such as glioma, ovarian cancer, breast cancer, pancreatic cancer to name a few. RGD conjugated lipids can be used to prepare liposomes to achieve targeted delivery of the anti-cancer agents to the cells which overexpress these receptors. The cells will internalize the RGD containing peptide via integrin-mediated endocytosis. As a result, the targeted liposomes avoid off target effects, a major side effect of many cancer therapies.
The RGD-functionalized liposomes synthesized from the NanoFabTx™ RGD Lipid Mix enable users to 1) encapuslate a wide variety of small molecules and 2) selectively target cells which overexpress RGD-binding integrins, such as cancer cells, without the need for lengthy trial-and-error optimization.
RGD has high affinity to integrins (including alpha V beta 3) which are overexpressed on cancer cells such as glioma, ovarian cancer, breast cancer, pancreatic cancer to name a few. RGD conjugated lipids can be used to prepare liposomes to achieve targeted delivery of the anti-cancer agents to the cells which overexpress these receptors. The cells will internalize the RGD containing peptide via integrin-mediated endocytosis. As a result, the targeted liposomes avoid off target effects, a major side effect of many cancer therapies.
The RGD-functionalized liposomes synthesized from the NanoFabTx™ RGD Lipid Mix enable users to 1) encapuslate a wide variety of small molecules and 2) selectively target cells which overexpress RGD-binding integrins, such as cancer cells, without the need for lengthy trial-and-error optimization.
特点和优势
- A ready-to-use lipid blend for the synthesis of RGD targeted liposomes
- Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- RGD ligand enables targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
For more information, please refer to the protocol under the Protocol section of this page.
法律信息
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
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