934372
MC-Val-Cit-PAB-PNP
≥95%
Synonym(s):
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
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About This Item
Empirical Formula (Hill Notation):
C35H43N7O11
CAS Number:
Molecular Weight:
737.76
Beilstein:
10322169
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
[N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N
InChI key
HYSPJPGXSALJRR-DHIFEGFHSA-N
Application
This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).
Features and Benefits
The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Qinhuai Lai et al.
European journal of medicinal chemistry, 199, 112364-112364 (2020-05-14)
Cryptophycin-52 (CR52), a tubulin inhibitor, exhibits promising antitumor activity in vitro (picomolar level) and in mouse xenograft models. However, the narrow therapeutic window in clinical trials limits its further development. Antibody-drug conjugate (ADC), formed by coupling cytotoxic compound (payload) to an
Zixuan Ye et al.
International journal of nanomedicine, 16, 2443-2459 (2021-04-06)
Specific modifications to carriers to achieve targeted delivery of chemotherapeutics into malignant tissues are a critical point for efficient diagnosis and therapy. In this case, bovine serum albumin (BSA) was conjugated with cetuximab-valine-citrulline (vc)-doxorubicin (DOX) to target epidermal growth factor
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