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Merck
CN

934801

Glycidol chitosan

Degree of functionalization > 80%

Synonym(s):

Dihydroxypropyl chitosan, Glycolchitosan, glycol chitosan

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About This Item

Linear Formula:
[C9H17NO6]n [C8H13NO5]m
NACRES:
NA.21
UNSPSC Code:
12352201
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form

powder or chunks (or fibres)

color

white to off-white

storage temp.

2-8°C

Quality Level

General description

Chitosan is a cationic biodgradable and biocompatible biopolymer that has been commonly used in many applications. The polymer chains are positively charged when disolved in aqueous solutions of pH<6.5. However, the biomedical applications of the positively charged chitosan are limited becuase it cannot be easily dissolved in aqueous media. Glycidol chitosan is a derivative of chitosan whereby hydrohilic glycidol is grafted onto the amino groups of chitosan to improve its solubility in a wider range of pH. It possesses many useful biological properties such as biocompatibility, biodegradability, and antimicrobial properties. It can also be further functionalized to induce photo and thermally crosslinkable properites and can be used as a precursor for hydrogel preparations that can be used in many biomedical applications.

Application

  • Hydrogels
  • Tissue engineering
  • Bioprinting
  • Drug delivery system

Features and Benefits

  • Naturally derived biopolymer
  • Cationic
  • Enhanced solubility
  • Tunable precursor material

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Evaluation of the biological properties of soluble chitosan and chitosan microspheres
Carreno-Gomez, B
International Journal of Pharmaceutics, 148 (1997)
Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery
Fengming Lin
Molecules (Basel), 24 (2009)
Chitosan chemistry and pharmaceutical perspectives
Kumar MR
Chemical Reviews, 104 (2004)
Effect of chitosan dissolved in different acids on its ability to control postharvest gray mold of table grape
Romanazzi G
Phytopathology, 99(9) (2009)
H Ueno et al.
Biomaterials, 20(15), 1407-1414 (1999-08-24)
Chitosan is a polymeric beta(1 --> 4) glucosamine (2-amino-2-deoxy-D-glucose) and N-acetyl-D-glucosamine (2-acetamido-2-deoxy-D-glucose) which has been reported as a wound healing accelerator. In order to evaluate the efficacy of chitosan as an accelerator of wound healing, experimental open skin wounds were

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