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Merck
CN

935166

Hyaluronic acid

acid form, average Mw 25,000

Synonym(s):

HA

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About This Item

Linear Formula:
(C14H21NO11)n
CAS Number:
9004-61-9
MDL number:
MFCD00131348
UNSPSC Code:
51202002
NACRES:
NA.21

Key Documents

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Product Name

Hyaluronic acid, acid form, average Mw 25,000

InChI key

KIUKXJAPPMFGSW-UHFFFAOYSA-N

InChI

1S/C28H44N2O23/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45)

SMILES string

N(C1C(OC(C(C1OC4OC(C(C(C4O)O)O)C(=O)O)O)CO)OC2C(OC(C(C2O)O)OC3C(C(OC(C3O)CO)O)NC(=O)C)C(=O)O)C(=O)C

description

acid form of hylauronic acid

form

powder or chunks (or Fibers)

mol wt

average Mw 25,000

color

white to faint yellow, Faint Brown

application(s)

advanced drug delivery
(Tissue engineering)

storage temp.

2-8°C

Quality Level

100

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Related Categories

Application

  • Tissue engineering including cartilage tissue engineering, bone tissue engineering, and other musculoskeletal tissues
  • Drug delivery and a carrier of small molecules, large molecules, and biomolecules
  • Biosensors, films and transdermal microneedles development
  • Medical device coatings, wound healing, and cosmetics

Features and Benefits

  • The same advantages of HA but in acid form
  • Soluble in organic solvents such as DMSO
  • Larger range of chemical modifications and functionalization possibilities

General description

Hyaluronic acid (HA) is a a natural polymer found in many extracellular matrices (ECM). Its biocompatibility, biodegradability, and biomimetic chacteristics make it one of the most advantagous biopolymers for myriad of biomedical applications including drug delivery, tissue engineering, hydrogel development, cosmetics, regenerative medicine and 3D bioprinting.
Unlike other HA products which are typically available in a sodium salt form, HA acid form is soluble in organic solvents such as DMSO. This allows for a larger range of possible chemical modifications and functionalization. For instance, the carboxylic acid of the glucoronic acid can be modified or functionalized with hydrazine end groups.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ4240
MKCZ1468
MKCX7238
MKCV8811
MKCX6940

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Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments-What Are the Capabilities?
Griesser J, et al.
Polymers (Basel, Switzerland), 28, 243-243 (2018)
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
Gupta R C, et al.
Frontiers in veterinary science, 25, 192-192 (2019)
A mild and straightforward one-pot hyaluronic acid functionalization through termination of poly-(2-alkyl-2-oxazoline)
Madau M, et al.
Polymer, 230, 124059-124059 (2021)

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