936219
AdQPhos Pd(crotyl)Cl
powder
Sustainability features
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About This Item
Empirical Formula (Hill Notation):
C64H66ClFePPd
Molecular Weight:
1063.90
UNSPSC Code:
12352142
NACRES:
NA.21
eCl@ss:
32150313
Product Name
AdQPhos Pd(crotyl)Cl,
form
powder
Quality Segment
reaction suitability
reaction type: Cross Couplings
sustainability
Sustainability features
color
light red to red, and Pink
functional group
(palladium), phosphine
SMILES string
Cl[Pd]([P](C12C[C@H]3C[C@H](C[C@H](C3)C2)C1)(C45C[C@H]6C[C@H](C[C@H](C6)C5)C4)c7cccc7)C.CCCC.c8(C9=CC=CC=C9)c(C%10=CC=CC=C%10)c(C%11=CC=CC=C%11)c(C%12=CC=CC=C%12)c8C%13=CC=CC=C%13.[Fe]
General description
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The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.
Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.
Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.
Application
In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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