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Sigma-Aldrich

Poly(propylene fumarate)

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contains contains ~20 wt% diethyl fumarate & 250 ppm MEHQ as inhibitor

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Synonym(s):
PPF
Linear Formula:
C3H8O2(C7H8O4)n

form

viscous liquid (Paste)

Quality Level

100

contains

contains ~20 wt% diethyl fumarate & 250 ppm MEHQ as inhibitor

color

colorless, White

storage temp.

−20°C

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General description

Poly(propylene fumarate) (PPF), a biodegradable polyester, contains unsaturated fumarate group which allows cross-linking of the polymer into a covalent polymer network and has been widely investigated for tissue engineering applications due to adjustable biodegradability, biocompatibility and mechanical performance.

Application

  • A degradable scaffold material for bone tissue engineering
  • Cross-linkable scaffolds synthesis
  • In the drug delivery system

Features and Benefits

  • Better biocompatibility and biodegradability
  • Unsaturated fumarate sites for crosslinking
  • Upon hydrolysis of PPF′s ester linkage, it degrades into biocompatible and excretable fumaric acid and propylene glycol

Regulatory Information

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Ana M Diez-Pascual
Polymers, 9(7), 260-260 (2017-06-30)
Poly(propylene fumarate) (PPF) is a linear and unsaturated copolyester based on fumaric acid that has been widely investigated for tissue engineering applications in recent years due to its tailorable mechanical performance, adjustable biodegradability and exceptional biocompatibility. In order to improve
Zhongyu Cai et al.
Biomaterials, 208, 45-71 (2019-04-17)
Poly(propylene fumarate) (PPF) is a biodegradable polymer that has been investigated extensively over the last three decades. It has led many scientists to synthesize and fabricate a variety of PPF-based materials for biomedical applications due to its controllable mechanical properties
F Kurtis Kasper et al.
Nature protocols, 4(4), 518-525 (2009-03-28)
This protocol describes the synthesis of 500-4,000 Da poly(propylene fumarate) (PPF) by a two-step reaction of diethyl fumarate and propylene glycol through a bis(hydroxypropyl) fumarate diester intermediate. Purified PPF can be covalently cross-linked to form degradable polymer networks, which have

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