938238
Silica
monodisperse, non-porous, 5 μm
Synonym(s):
Monodisperse silicon dioxide, Non-porous silica, Non-porous silicon dioxide, Silicon dioxide
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About This Item
Linear Formula:
SiO2
CAS Number:
Molecular Weight:
60.08
UNSPSC Code:
12352309
NACRES:
NA.21
MDL number:
Product Name
Silica, monodisperse, non-porous, 5 μm
InChI
1S/O2Si/c1-3-2
SMILES string
O=[Si]=O
InChI key
VYPSYNLAJGMNEJ-UHFFFAOYSA-N
form
powder
particle size
5 μm
pore size
non-porous
bp
2230 °C (lit.)
mp
>1600 °C (lit.)
Quality Level
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Application
Monodisperse, non-porous silica particles have several applications in various research areas including drug delivery, molecular imaging, and environmental remediation. Owing to their stable chemical structure, ease of surface modification, and affinity toward various biomolecules, silica microparticles are an attractive platform for bioconjugation of drugs, proteins, DNA, and other biomarkers. Consequently, non-porous silica particles and their bioconjugates are used in biomedical applications for delivering or isolating drugs, proteins, polynucleotides, and more. Bioconjugation of non-porous silica often facilitates imaging techniques including optical imaging (fluorescence and bioluminescence), magnetic resonance imaging (MRI), radionuclide imaging, computed tomography (CT), ultrasound, photoacoustic imaging, and Raman imaging.,Apart from these applications, these monodisperse particles are also used in analytical applications, such as the stationary phase in columns for advanced, high-performance liquid chromatography.
General description
Our monodisperse, non-porous silica powder is a white powder composed of speherical particles, precisely engineered to achieve a monodisperse particle size of 5 µm with 99.99% purity. The microparticles do not contain any internal porosity or void spaces, making their surfaces impermeable to fluids or gases.
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Safety of Nonporous Silica Nanoparticles in Human Corneal Endothelial Cells
Kim J Y, et al
Scientific Reports, 7, 14566-14566 (2017)
Core-shell particles lead the way to renewing high-performance liquid chromatography
Gonzalez-Ruiz V, et al
TrAC, Trends in Analytical Chemistry, 64, 17-28 (2015)
Nonporous Silica Nanoparticles for Nanomedicine Application
Tang L, et al.
Nano Today, 8, 290-312 (2013)
Sean E Lehman et al.
Langmuir : the ACS journal of surfaces and colloids, 32(3), 731-742 (2015-12-31)
Understanding complex chemical changes that take place at nano-bio interfaces is of great concern for being able to sustainably implement nanomaterials in key applications such as drug delivery, imaging, and environmental remediation. Typical in vitro assays use cell viability as
Nano-Bio Interactions of Porous and Nonporous Silica Nanoparticles of Varied Surface Chemistry: A Structural, Kinetic, and Thermodynamic Study of Protein Adsorption from RPMI Culture Medium
Lehman S, et al.
Langmuir, 32, 731-742 (2016)
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