Copper(II) acetate

Copper(II) acetate also known as cupric acetate, can be used as a catalyst and as a Cu precursor in chemical synthesis. It is particularly useful in cross-coupling reactions, where it can promote the formation of carbon-carbon or carbon-heteroatom bonds, without the need for hazardous reagents or solvents. Commonly used in CuAAC ′click′ chemistry as a copper source.

Copper(II) acetate has been used in:

• The synthesis of heterocyclic sulfonium triflates by Cu-catalyzed S-arylation with aryl(mesityl)iodonium salts
• The copper-catalyzed N-formylation of amines with CO₂ in the presence of silanes
• The ssymmetric synthesis of trisubstituted vicinal Diols by copper(I)-catalyzed diastereoselective and enantioselective allylation of ketones
• The copper(II)-catalyzed enantioselective decarboxylative Mannich reaction coordinated by supramolecular organic amine cages
• The B/Cu catalyzed asymmetric Mannich reaction between β,γ-Alkynyl-α-ketimino esters and ortho-hydroxy aryl ketones
• The Cu(II)-Catalyzed hydrofunctionalization of unactivated alkynes via π-lewis acid activation

This high quality copper(II) acetate is tested to be extremely low in iron, potassium and aluminium impurities. It is suitable for use in further copper mediated synthesis and catalysis, especially in copper mediated azide-alkyne cycloaddition click chemistry (CuAAC).