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A76109

3-Amino-1-propanesulfonic acid

Name: 3-Amino-1-propanesulfonic acid
Brand: ALDRICH

97%

Synonym(s):

3APS, Homotaurine, Tramiprosate

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About This Item

Linear Formula:

H₂N(CH₂)₃SO₃H

CAS Number:

3687-18-1

Molecular Weight:

139.17

NACRES:

NA.22

PubChem Substance ID:

24891257

UNSPSC Code:

12352100

EC Number:

222-977-4

MDL number:

MFCD00008225

Assay:

97%

Form:

solid

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Properties

Quality Level

100

assay

97%

form

solid

mp

293 °C (dec.) (lit.)

SMILES string

NCCCS(O)(=O)=O

InChI

1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChI key

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

Description

Application

Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Domain-specific cognitive effects of tramiprosate in patients with mild to moderate Alzheimer's disease: ADAS-cog subscale results from the Alphase Study.

D Saumier et al.

The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)

Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the

Precolumn derivatization followed by liquid chromatographic separation and determination of tramiprosate in rat plasma by fluorescence detector: application to pharmacokinetics.

R Nageswara Rao et al.

Journal of pharmaceutical and biomedical analysis, 55(2), 282-287 (2011-02-18)

Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of

Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study.

S Gauthier et al.

The journal of nutrition, health & aging, 13(6), 550-557 (2009-06-19)

The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of

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Global Trade Item Number

SKU	GTIN
A76109-1G	04061825899466
A76109-5G	04061832421223