A76109
3-Amino-1-propanesulfonic acid
97%
Synonym(s):
3APS, Homotaurine, Tramiprosate
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About This Item
Linear Formula:
H2N(CH2)3SO3H
CAS Number:
Molecular Weight:
139.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
222-977-4
MDL number:
Assay:
97%
Form:
solid
InChI key
SNKZJIOFVMKAOJ-UHFFFAOYSA-N
InChI
1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
SMILES string
NCCCS(O)(=O)=O
assay
97%
form
solid
mp
293 °C (dec.) (lit.)
Quality Level
Related Categories
Application
Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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D Saumier et al.
The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the
S Gauthier et al.
The journal of nutrition, health & aging, 13(6), 550-557 (2009-06-19)
The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of
J Y Wu et al.
Journal of biomedical science, 8(1), 96-103 (2001-02-15)
Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its action through the taurine system rather than the glutamatergic or GABAergic system. This conclusion is based on the observations
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 55(2), 282-287 (2011-02-18)
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of
M Foster Olive et al.
European journal of pharmacology, 437(1-2), 55-61 (2002-02-28)
The purpose of the present study was to determine the acute effects of the anticraving compound acamprosate (calcium acetylhomotaurinate) and the closely related compound homotaurine on ethanol intake and ethanol-stimulated dopamine release in the nucleus accumbens. Male rats were treated
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