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ALD00558

1-((3,5-Difluorophenyl)sulfonyl)bicyclo[1.1.0]butane

Name: 1-((3,5-Difluorophenyl)sulfonyl)bicyclo[1.1.0]butane
Brand: ALDRICH

95%

Synonym(s):

Baran cyclobutylation reagent

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₈F₂O₂S

Molecular Weight:

230.23

UNSPSC Code:

12352101

NACRES:

NA.22

PubChem Substance ID:

329772718

Assay:

95%

Form:

powder or crystals

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Properties

Quality Segment

100

assay

95%

form

powder or crystals

reaction suitability

reaction type: C-C Bond Formation

storage temp.

2-8°C

Description

General description

1-((3,5-Difluorophenyl)sulfonyl)bicyclo[1.1.0]butane can be used as a cyclobutylation agent to introduce bicyclobutane group onto a variety of amines and thiols without affecting other functional groups.

Application

The following "spring-loaded" electrophile is a convenient reagent for the installation of cyclobutane to primary and secondary amines. This product is one of several synthetically useful reagents reported by Baran and coworkers on strain-release amination.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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