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Merck
CN

ALD00613

Sigma-Aldrich

PSI2

Synonym(s):

Ψ2, 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent

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About This Item

Empirical Formula (Hill Notation):
C8H4F5OPS3
Molecular Weight:
338.28
UNSPSC Code:
12352005
NACRES:
NA.22

Key Documents

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form

powder

Quality Level

100

mp

94-97 °C

Application

PSI2 is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI2 are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI2 and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).

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Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV3413

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Articles

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

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